Table 2 ERK-5 overexpression enhances biomechanical property of rats’ femurs
GroupshamOvariectomized rat
OVXOVX + NCOVX + ERK-5 shRNAOVX + ERK-5 overexpression
Maximum loads (N)117.68 ± 5.2994.59 ± 5.26*94.83 ± 7.81*80.06 ± 6.45*105.37 ± 6.30*
Breaking load (N)96.73 ± 5.3470.09 ± 5.86*69.58 ± 7.66*52.11 ± 4.72*83.76 ± 5.49*
Energy absorption (N.mm)82.41 ± 5.8752.56 ± 7.12*51.34 ± 5.94*32.57 ± 3.62*69.44 ± 6.36*
Structural stiffness (N.mm−1)199.57 ± 11.26160.56 ± 9.18*153.80 ± 10.67*112.92 ± 6.59*177.66 ± 10.84*
Maximum bending moment (N.mm)711.5 ± 51.35548.81 ± 63.12*529.46 ± 44.13*450.68 ± 27.62*634.07 ± 39.72*
Elasticity modulus (N.mm−1)5997.10 ± 171.304833 ± 121.8*4736.50 ± 153.90*3655.80 ± 131.50*5367.20 ± 158.40*
Ultimate strength (N.mm−2)176.43 ± 11.91134.21 ± 13.52*129.76 ± 14.21*108.82 ± 9.83*155.24 ± 13.32*
Breaking strength (N.mm−2)168.61 ± 13.33119.63 ± 10.46*117.12 ± 14.20*96.71 ± 8.81*140.35 ± 13.42*
Maximum strain (%)5.65 ± 0.562.71 ± 0.31*2.70 ± 0.25*1.97 ± 0.57*3.54 ± 0.34*
Breaking strain (%)7.96 ± 0.904.57 ± 1.1*4.55 ± 0.75*3.30 ± 0.35*5.84 ± 1.30*
  • Abbreviation: ERK-5 siRNA, ERK-5 small interfering RNA.

    *, P<0.05 vs. the normal group.

    , P<0.05 vs. the postmenopausal osteoporosis group.