Table 2

Results of overall and subgroup analyses

PolymorphismsPopulationSample sizeDominant comparisonRecessive comparisonOver-dominant comparisonAllele comparison
Cases/ ControlsP valueOR (95%CI)I2P valueOR (95%CI)I2P valueOR (95%CI)I2P valueOR (95%CI)I2
LEPR rs1137100Overall798/18410.800.91 (0.43–1.92)76%0.421.08 (0.90–1.29)0%0.640.96 (0.80–1.15)4%0.350.93 (0.81–1.08)31%
Caucasian377/12910.850.88 (0.24–3.20)88%0.751.04 (0.82–1.32)0%0.931.01 (0.80–1.28)37%0.740.95 (0.70–1.29)65%
LEPR rs1137101Overall1235/21560.170.76 (0.52–1.13)81%0.621.12 (0.72–1.72)73%0.491.09 (0.86–1.38)53%0.310.85 (0.63–1.16)85%
East Asian621/6500.610.70 (0.18–2.76)95%0.801.19 (0.31–4.61)89%0.940.98 (0.58–1.66)71%0.670.79 (0.27–2.32)96%
South Asian236/2100.100.72 (0.49–1.06)46%0.921.07 (0.29–3.99)87%0.061.46 (0.99–2.16)44%0.620.83 (0.39–1.75)86%
Caucasian378/12960.310.87 (0.67–1.13)0%0.441.12 (0.84–1.50)0%0.761.04 (0.82–1.31)5%0.270.91 (0.77–1.08)0%
MI306/4940.270.71 (0.39–1.30)60%0.051.39 (0.99–1.94)40%0.730.95 (0.71–1.27)0%0.180.73 (0.47–1.15)70%
LEP rs7799039Overall1136/9890.270.78 (0.50–1.21)82%0.380.77 (0.43–1.38)78%0.00071.36 (1.14–1.63)41%0.670.92 (0.64–1.34)87%
East Asian754/4450.460.76 (0.36–1.59)89%0.500.70 (0.25–1.96)86%0.041.50 (1.02–2.20)59%0.790.92 (0.48–1.75)92%
  • The values in bold represent statistically significant differences between cases and controls. Abbreviation: MI, myocardial infarction.