Table 2 Univariate and multivariate Cox regression of prognostic factors for overall survival in osteosarcoma patients
ParameterUnivariate analysisMultivariate analysis
HR95% CIPHR95% CIP
Age (years)
  (≤18 vs. >18)0.8420.547–1.2960.435
Gender
  (Female vs. Male)1.1450.732–1.7910.553
Enneking stage
  (I-III A vs. II B-III)3.7232.176–6.370<0.0011.8980.874–4.1240.047
Tumor size
  (≤8 vs. >>8 cm)1.8801.223–2.8920.0041.3580.868–2.1240.180
Distant metastasis
  (Absence vs. Presence)5.6113.230–9.748<0.0013.1521.748–5.684<0.001
Histological grade
  (G1-G2 vs.G3-G4)2.7541.722–4.405<0.0011.3880.729–2.6440.319
Tumor site
  (Femur/Tibia vs. Other)1.6120.980–2.6520.060
LSINCT5 expression
  (Low vs. High)2.9251.864–4.591<0.0011.6751.017–2.7590.043
  • Abbreviations: HR, hazard ratio; 95% CI, 95% confidence interval.