Table 3 Association of GSPT2 variant rs974285 with HBV outcomes
Cases, n (%)Controls, n (%)CodominantDominantRecessive
TTCTCCTTCTCCOR (95% CI)POR (95% CI)POR (95% CI)P
HBV susceptibilityCIB (n=769)Healthy (n=483)
295968119344301.113 (0.709, 1.7481)10.64121.048 (0.730, 1.505)0.7980.957 (0.531, 1.727)0.884
(3.8)(7.7)(88.6)(3.9)(7.0)(89.0)1.016 (0.554, 1.864)10.958b1.079 (0.744, 1.564)10.68921.008 (0.550, 1.847)10.9792
HBV NCCIB (n=769)NC (n=322)
295968114272810.884 (0.545, 1.434)10.61820.886 (0.596, 1.316)0.5470.862 (0.449, 1.654)0.655
(3.8)(7.7)(88.6)(4.3)(8.4)(87.3)0.755 (0.465, 1.7431)10.75520.890 (0.596, 1.329)10.56820.909 (0.470, 1.759)10.7782
CHB→LCLC (n=248)CHB (n=213)
10212178141911.113 (0.651, 2.067)10.71621.240 (0.694, 2.215)0.4661.077 (0.417, 2.773)0.879
(4.0)(8.5)(87.5)(3.8)(6.6)(89.7)1.130 (0.487, 2.815)10.78521.192 (0.693, 1.910)10.49721.107 (0.467, 3.150)10.8352
CHB+LC→ HCCHCC (n=308)CHB+LC (n=461)
112427318354080.958 (0.534, 1.628)10.88020.987 (0.627, 1.553)0.9550.912 (0.424, 1.958)0.812
(3.6)(7.8)(88.6)(3.9)(7.6)(88.5)1.009 (0.480, 2.364)10.98221.006 (0.602, 1.588)10.98120.993 (0.516, 2.368)10.9862
  • Abbreviations: CIB, HBV infection.

  • 1OR and OR 95% CI adjusted for age, sex, smoking status, drinking status, HBV DNA, HbeAg (+/−).

  • 2α value is adjusted by Bonferroni’s correction and statistically significant results (P<0.025).