Table 1 Clinical and echocardiography features from population of the study
BAG3-/DCM-N:20BAG3-/DCM+N: 21BAG 3+/DCM+N:14BAG3+/DCM-N:7
AGE40.92 ± 15.4738.86 ± 14.6845.21 ± 10.0026.29 ± 17.43
SEX (male%)1011103
WEIGHT (kg)71.29 ± 14.6674.88 ± 19.1386.29 ± 15.2258.00 ± 14.97
HEIGHT (cm)168.92 ± 10.62165.96 ± 29.50174.21 ± 11.97145 ± 53.52
DYSPHNEA (+)030.181.2, P<0.001§0
PALPITATIONS (+)032.6 P<0.00168.828.6, P<0.001
HR (bpm)71.92 ± 9.5087.04 ± 9.7968.23 ± 11.0071.33 ± 6.68
SBP (mmHg)127.42± 17.02128.63 ± 13.12133.08 ± 11.41121.33 ± 12.06
DBP (mmHg)70.29 ± 12.4177.04 ± 10.9283.22 ± 7.3976.00 ± 13.43
LVEF (%)66.81 ± 7.1745.20 ± 12.40*47.21 ± 12.00†57.71 ± 5.64
TDLVD (mm)48.05 ± 4.6855.94 ± 8.9956.98 ± 8.6547.98 ± 7.86
TSLVD (mm)32.20 ± 6.171437.65 ± 10.2642.96 ± 10.1832.40 ± 5.97
TAPSE RV (cm)21.58 ± 3.1221.33 ± 3.2321.35 ± 4.2721.74 ± 1.22
LA Area (cm2)17.26 ± 2.3118.24 ± 4.3219.80 ± 3.4015.12 ± 4.50
RA Area (cm2)13.67 ± 3.0414.56 ± 3.9716.11 ± 3.8712.12 ± 2.91
LA length (mm)48.02 ± 4.8252 ± 9.0760.59 ± 6.0344.24 ± 4.55
RA length (mm)45.54 ± 7.0845.99 ± 7.0652.70 ± 5.3541.67 ± 5.15
E wave (m/s)0.79 ± 0.140.79 ± 0.180.75 ± 0.230.86 ± 0.20
A wave (m/s)0.55 ± 0.250.66 ± 0.220.70 ± 0.250.55 ± 0.14
E/A1.34 ± 0.391.33 ± 0.451.14 ± 0.391.67 ± 0.60
A septal
Stdi (cm/s)7.87 ± 1.4837.82±1.437.5 ± 01.508.45 ± 1.11
Etdi8.72 ± 2.5869.18±2.788.06 ± 1.6411.40 ± 3.37
Atdi7.68 ± 2.6099.49±2.1110.36 ± 1.857.72 ± 1.45
A lateral
Stdi10.40 ± 2.5510.19 ± 2.469.81 ± 2.4910.94 ± 2.38
Etdi11.92 ± 4.4812.90 ± 4.5911.17 ± 3.2316.35 ± 5.17
Atdi9.14 ± 3.0310.24 ± 2.3410.18 ± 2.3210.34 ± 2.58
Fibrosis (+)026.562.528.6£
Knock (+)030.543.842.9
  • BAG3 mutation carriers were divided into phenotypically negative (phenot -) or positive (phenot+) based on the presence of dysphnea and left ventricle disfunction.

  • Abbreviations: HR, heart rate; SBP, systolic blood pressure; DAP, dyastolic blood pressure; LVEF, left ventricle ejection fraction; TDLVD, telediastolic left ventricle diameter; TSLVD, telesistolic left ventricle diameter; TAPSE RV, tricuspid anular plane sistolic exceursion of the right ventricle; LA Area, left atrium area; RA area, right atrium area; Fibrosis +, presence of fibrosis; Knock +, presence of knock. * P<10−4 LVEF BAG3-/DCM- vs BAG3-/DCM+. P<4x10−3 LVEF BAG3-/DCM+ vs BAG3+/DCM+. ‡ P<6x10−3 LA LENGHT BAG3-/DCM+ vs BAG3+/DCM+. § P<0.001 DYSPHNEA BAG3-/DCM+ vs BAG3+/DCM+. ║ P<0.001 PALPITATIONS BAG3-/DCM+ vs BAG3+/DCM+ AND BAG3+/DCM+ vs BAG3+/DCM-. P<0.001 PALPITATIONS BAG3-/DCM+ vs BAG3+/DCM+. £ P<0.001 PALPITATIONS BAG3+/DCM+ vs BAG3+/DCM-.