Table 7 Influence of AP-2α and AP-2γ factors on selected developmental processes, diseases, and interactive molecules (based on GeneCards, Reactome databases, and Atlas of Genetics and Cytogenetics in Oncology and Haematology)
AP-2αAP-2γ
Participation in development processess – majorFace, eye, limb, body wall, neural tube development
Participation in development processess – otherEarly morphogenesis of lens vesicle; kidney developmentMale gonad development
Associated diseasesBOFS; ectopic thymus; anophthalmia-microphthalmia syndromeExencephaly; melanoma; pre-eclampsia
Mutual interactionsInteracts with WWOX, CITED2, CITED4, UBE2I, KCTD1, KCTD15, EP300; Suppresses MCAM/MUC18, C/EBPα; Stimulates transcriptional activation of PITX2
Exclusive interactionsAlong with binding NPM1 – represses HSPD1 gene expression, inhibiting formation of mitochondrial chaperonin;Along with MTA1 – mediates epigenetic regulation of ESR1 expression in breast cancer (BCa); Interacts with KDM5B
Stimulates APOE gene transcription in co-operation with DEK;
Interacts with RALBP1 (in complex containing NUMB and EPN1) during interphase and mitosis