Table 3 Subgroup analyses between GDF5/rs143383 gene polymorphism and the risk of KOA
Variablesrs143383 (Case/control)TT vs CCCT vs CCTT/CT vs CCTT vs CT/CCT vs C
TTCTCCOR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)P
Sex
  Male56/9747/7426/143.22 (1.55–6.66)0.0021.10 (0.67–1.80)0.7041.43 (0.91–2.26)0.1163.08 (1.54–6.17)0.0011.64 (1.17–2.30)0.004
  Female68/10958/8533/182.94 (1.54–5.63)0.0011.09 (0.70–1.72)0.6971.42 (0.94–2.14)0.0992.82 (1.52–5.23)0.0011.76 (1.31–2.36)0.000
Age (years)
  ≥6068/12764/9941/203.83 (2.08–7.05)0.0001.21 (0.79–1.86)0.3911.65 (1.11–2.45)0.0133.51 (1.97–6.24)0.0001.85 (1.39–2.48)0.000
  <6056/7941/6018/122.12 (0.94–4.74)0.0690.96 (0.57–1.63)0.9641.16 (0.71–1.88)0.5582.15 (0.99–4.67)0.0531.31 (0.90–1.89)0.159
Smoking
  Yes36/8641/5225/183.31 (1.68–6.54)0.0000.82 (0.54–1.24)0.3351.10 (0.75–1.62)0.6113.63 (1.88–6.99)0.0002.05 (1.42–2.97)0.000
  No88/12064/10734/143.32 (1.62–6.82)0.0011.88 (1.07–3.31)0.0282.25 (1.35–3.77)0.0022.49 (1.28–4.85)0.0071.41 (1.06–1.89)0.019
Drinking
  Yes34/6532/4814/164.41 (2.35–8.26)0.0001.03 (0.69–1.53)0.8831.46 (1.01–2.10)0.0434.35 (2.38–7.95)0.0001.54 (1.06–2.25)0.024
  No90/14173/11145/161.67 (0.73–3.83)0.2241.28 (0.69–2.35)0.4361.37 (0.78–2.41)0.2681.50 (0.69–3.26)0.3091.77 (1.35–2.33)0.000
BMI
  ≥2455/8045/7126/162.36 (1.16–4.81)0.0180.92 (0.56–1.53)0.7531.18 (0.75–1.89)0.4702.45 (1.25–4.81)0.0091.40 (1.00–1.98)0.053
  <2469/12660/8833/163.77 (1.94–7.33)0.0001.25 (0.80–1.93)0.3291.63 (1.09–2.45)0.0183.42 (1.81–6.46)0.0001.80 (1.33–2.45)0.000