Table 2 Meta-analysis of association between TLR4 polymorphism and HCV infection
Genetic modelsModels*OR (95% CI)P-valueI2 (%)P-value
rs4986791
C vs T (Allele contrast)RE1.74 (0.84;3.60)0.1477.10.005
CC vs TT (Homozygous)FE1.50 (0.29;7.82)<0.00010.00.856
CT vs TT (Heterozygous)FE0.95 (0.18;5.14)0.960.00.909
CC vs CT (Heterozygous)RE1.73 (0.78;3.83)0.1779.00.003
CC+CT vs TT (Dominant model)FE1.42 (0.27;7.37)0.680.00.881
CC vs CT + TT (Recessive model)RE1.76 (0.08;3.88)0.1679.10.003
CT vs CC+TT (Overdominant model)RE0.58 (0.26;1.28)0.1879.00.003
rs4986790
A vs G (Allele contrast)RE0.94 (0.26;3.37)<0.000197.7<0.001
AA vs GG (Homozygous)RE0.58 (0.07;4.77)0.6193.4<0.001
AG vs GG (Heterozygous)FE0.33 (0.21;0.49)<0.00010.00.550
AA vs AG (Heterozygous)RE1.21 (0.41;3.56)0.7294.3<0.001
AA+AG vs GG (Dominant model)RE0.47 (0.10;2.08)0.3287.2<0.001
AA vs AG + GG (Recessive model)RE1.03 (0.26;4.00)0.9696.8<0.001
AG vs AA+GG (Overdominant model)RE0.67 (0.31;1.41)0.2988.5<0.001
rs2149356
T vs G (Allele contrast)RE1.23 (0.47;3.28)0.6790.60.001
TT vs GG (Homozygous)RE3.84 (0.19;78.57)0.3884.20.012
TG vs GG (Heterozygous)RE1.45 (0.14;15.14)0.7677.90.034
TT vs TG (Heterozygous)FE2.17 (1.32;3.58)0.0022.10.257
TT+TG vs GG (Dominant model)RE1.87 (0.14;25.24)0.6481.90.019
TT vs TG + GG (Recessive model)RE2.09 (0.71;6.16)0.1873.80.051
TG vs TT+GG (Overdominant model)FE0.54 (0.40;0.75)<0.00010.00.684
  • * Meta-analysis models; FE, fixed-effect model; RE, random effect model .

  • OR P-value.

  • heterogeneous P-value.