polymorphism | Comparison | No. of | Test of associations | Test of heterogeneity | Model | Egger’s test | Sensitivity analysis | |||
---|---|---|---|---|---|---|---|---|---|---|
Studies | OR (95%CI) | P value | I2(%) | P value | P value | OR (95%CI) | P value | |||
-397 T/C PvuII (rs2234693) | ||||||||||
Severe preeclampsia | ||||||||||
C vs. T | 7 | 1.02(0.87,1.21) | 0.796 | 0 | 0.892 | F | 0.880 | 0.99(0.83,1.20) | 0.960 | |
CC+CT vs. TT | 7 | 1.05(0.81,1.37) | 0.713 | 0 | 0.890 | F | 0.520 | 0.99(0.74,1.32) | 0.917 | |
CC vs. TT+CT | 7 | 1.01(0.76,1.33) | 0.963 | 0 | 0.935 | F | 0.438 | 1.01(0.74,1.35) | 0.982 | |
CC vs. TT | 7 | 1.04(0.74,1.45) | 0.828 | 0 | 0.900 | F | 0.874 | 0.99(0.68,1.43) | 0.953 | |
CC vs. CT | 7 | 0.99(0.74,1.33) | 0.954 | 0 | 0.949 | F | 0.325 | 1.01(0.74,1.39) | 0.941 | |
Mild preeclampsia | ||||||||||
C vs. T | 5 | 1.02(0.86,1.21) | 0.783 | 0 | 0.426 | F | 0.919 | 0.99(0.83,1.20) | 0.967 | |
CC+CT vs. TT | 5 | 1.08(0.83,1.43) | 0.562 | 0 | 0.627 | F | 0.996 | 1.02(0.75,1.38) | 0.907 | |
CC vs. TT+CT | 5 | 0.98(0.74,1.30) | 0.884 | 7 | 0.367 | F | 0.696 | 0.97(0.71,1.33) | 0.850 | |
CC vs. TT | 5 | 1.03(0.73,1.45) | 0.888 | 0 | 0.431 | F | 0.888 | 0.97(0.66,1.43) | 0.878 | |
CC vs. CT | 5 | 0.95(0.70,1.29) | 0.738 | 0 | 0.416 | F | 0.811 | 0.93(0.69,1.34) | 0.822 | |
-351 A/G XbaI (rs9340799) | ||||||||||
Severe preeclampsia | ||||||||||
G vs. A | 4 | 1.10(0.91,1.34) | 0.331 | 0.4 | 0.390 | F | 0.636 | 1.14(0.91,1.43) | 0.255 | |
GG+GA vs. AA | 4 | 0.97(0.74,1.28) | 0.846 | 5.8 | 0.407 | F | 0.205 | 1.01(0.74,1.36) | 0.979 | |
GG vs. AA+GA | 4 | 1.67(1.10,2.55) | 0.017a | 30.6 | 0.228 | F | 0.808 | 1.81(1.12,2.93) | 0.0161 | |
GG vs. AA | 4 | 1.43(0.90,2.28) | 0.125 | 14.2 | 0.321 | F | 0.925 | 1.54(0.91,2.60) | 0.106 | |
GG vs. GA | 4 | 1.81(1.17,2.82) | 0.008a | 38 | 0.184 | F | 0.858 | 1.97(1.19,3.27) | 0.0081 | |
Mild preeclampsia | ||||||||||
G vs. A | 3 | 1.03(0.83,1.28) | 0.764 | 0 | 0.563 | F | 0.337 | 1.04(0.81,1.35) | 0.747 | |
GG+GA vs. AA | 3 | 0.90(0.67,1.22) | 0.494 | 35.1 | 0.214 | F | 0.483 | 0.91(0.65,1.29) | 0.613 | |
GG vs. AA+GA | 3 | 1.13(0.67,1.91) | 0.647 | 0 | 0.545 | F | 0.212 | 1.04(0.54,2.01) | 0.897 | |
GG vs. AA | 3 | 1.12(0.64,1.97) | 0.697 | 0 | 0.858 | F | 0.047 | 1.11(0.56,2.23) | 0.759 | |
GG vs. GA | 3 | 1.15(0.67,1.96) | 0.619 | 14.3 | 0.311 | F | 0.202 | 1.03(0.52,2.02) | 0.941 |
↵a P<0.05.
Abbreviations: OR: odds ratio; 95% CI: 95% confidence interval; F: fixed effects model; R: random effects model; No.: number.