Table 2 Meta-analysis of associations between the ESR1 gene polymorphism and severe and mild preeclampsia
polymorphismComparisonNo. ofTest of associationsTest of heterogeneityModelEgger’s testSensitivity analysis
StudiesOR (95%CI)P valueI2(%)P valueP valueOR (95%CI)P value
-397 T/C PvuII (rs2234693)
Severe preeclampsia
C vs. T71.02(0.87,1.21)0.79600.892F0.8800.99(0.83,1.20)0.960
CC+CT vs. TT71.05(0.81,1.37)0.71300.890F0.5200.99(0.74,1.32)0.917
CC vs. TT+CT71.01(0.76,1.33)0.96300.935F0.4381.01(0.74,1.35)0.982
CC vs. TT71.04(0.74,1.45)0.82800.900F0.8740.99(0.68,1.43)0.953
CC vs. CT70.99(0.74,1.33)0.95400.949F0.3251.01(0.74,1.39)0.941
Mild preeclampsia
C vs. T51.02(0.86,1.21)0.78300.426F0.9190.99(0.83,1.20)0.967
CC+CT vs. TT51.08(0.83,1.43)0.56200.627F0.9961.02(0.75,1.38)0.907
CC vs. TT+CT50.98(0.74,1.30)0.88470.367F0.6960.97(0.71,1.33)0.850
CC vs. TT51.03(0.73,1.45)0.88800.431F0.8880.97(0.66,1.43)0.878
CC vs. CT50.95(0.70,1.29)0.73800.416F0.8110.93(0.69,1.34)0.822
-351 A/G XbaI (rs9340799)
Severe preeclampsia
G vs. A41.10(0.91,1.34)0.3310.40.390F0.6361.14(0.91,1.43)0.255
GG+GA vs. AA40.97(0.74,1.28)0.8465.80.407F0.2051.01(0.74,1.36)0.979
GG vs. AA+GA41.67(1.10,2.55)0.017a30.60.228F0.8081.81(1.12,2.93)0.0161
GG vs. AA41.43(0.90,2.28)0.12514.20.321F0.9251.54(0.91,2.60)0.106
GG vs. GA41.81(1.17,2.82)0.008a380.184F0.8581.97(1.19,3.27)0.0081
Mild preeclampsia
G vs. A31.03(0.83,1.28)0.76400.563F0.3371.04(0.81,1.35)0.747
GG+GA vs. AA30.90(0.67,1.22)0.49435.10.214F0.4830.91(0.65,1.29)0.613
GG vs. AA+GA31.13(0.67,1.91)0.64700.545F0.2121.04(0.54,2.01)0.897
GG vs. AA31.12(0.64,1.97)0.69700.858F0.0471.11(0.56,2.23)0.759
GG vs. GA31.15(0.67,1.96)0.61914.30.311F0.2021.03(0.52,2.02)0.941
  • a P<0.05.

  • Abbreviations: OR: odds ratio; 95% CI: 95% confidence interval; F: fixed effects model; R: random effects model; No.: number.