Table 3 Distribution of IL-17 rs763780, rs2275913, rs8193036 and NF-κB1 rs3774934 polymorphisms and ARDS risk
SNPCase group (n=210)Control group (n=210)P valueOR (95%CI)P value*OR (95%CI)*
IL-17 rs763780
Genotype
  AA180 (85.7%)185 (88.1%)Ref
  AG18 (8.6%)20 (9.5%)0.8190.925 (0.451–1.896)0.9540.961 (0.626–1.329)
  GG12 (5.7%)5 (2.4%)0.0862.467 (0.787–8.206)0.1421.431 (0.882–1.826)
  AA+AG198 (94.3%)205 (97.6%)Ref
  GG12 (5.7%)5 (2.4%)0.0832.485 (0.794–8.247)0.1371.437 (0.886–1.830)
  AA180 (85.7%)185 (88.1%)Ref
  AG+GG30 (14.3%)25 (11.9%)0.4701.233 (0.673–2.263)0.5631.106 (0.809–1.415)
Allele
  A378 (90.0%)390 (92.9%)Ref
  G42 (10.0%)30 (7.1%)0.1391.444 (0.862–2.425)0.1751.185 (0.927–1.438)
IL-17 rs2275913
Genotype
  GG158 (75.2%)89 (42.4%)Ref
  GA35 (16.7%)45 (21.4%)0.0010.438 (0.254–0.754)0.0020.684 (0.509–0.887)
  AA17 (8.1%)76 (36.2%)<0.0010.126 (0.067–0.234)<0.0010.286 (0.176–0.439)
  GG+GA193 (91.9%)134 (63.8%)Ref
  AA17 (8.1%)76 (36.2%)<0.0010.155 (0.084–0.283)<0.0010.310 (0.190–0.477)
  GG158 (75.2%)89 (42.4%)Ref
  GA+AA52 (24.8%)121 (57.6%)<0.0010.242 (0.156–0.375)<0.0010.470 (0.364–0.599)
Allele
  G351 (83.6%)223 (53.1%)Ref
  A69 (16.4%)197 (46.9%)<0.0010.223 (0.159–0.311)<0.0010.424 (0.340–0.523)
IL-17 rs8193036
Genotype
  CC74 (35.2%)137 (65.2%)Ref
  CT109 (51.9%)53 (25.2%)<0.0013.807 (2.414–6.017)<0.0011.919 (1.547–2.363)
  TT27 (12.9%)20 (9.5%)0.0042.499 (1.254–5.001)0.0071.638 (1.143–2.186)
  CC+CT183 (87.%)190 (90.5%)Ref
  TT27 (12.9%)20 (9.5%)0.2791.402 (0.729–2.703)0.3531.171 (0.846–1.496)
  CC74 (35.2%)137 (65.2%)Ref
  CT+TT136 (64.8%)73 (34.8%)<0.0013.449 (2.265–5.260)<0.0011.855 (1.504–2.289)
Allele
  C257 (61.2%)327 (77.9%)Ref
  T163 (38.8%)93 (22.1%)<0.0012.230 (1.629–3.054)<0.0011.447 (1.262–1.643)
NF-κB1 rs3774934
Genotype
  GG118 (56.2%)104 (49.5%)Ref
  GA49 (23.3%)49 (23.3%)0.6030.881 (0.533–1.458)0.6900.941 (0.726–1.189)
  AA43 (20.5%)57 (27.1%)0.0920.665 (0.402–1.099)0.1170.809 (0.609–1.048)
  GG+GA167 (79.5%)153 (72.9%)Ref
  AA43 (20.5%)57 (27.1%)0.1090.691 (0.429–1.114)0.1360.824 (0.625–1.054)
  GG118 (56.2%)104 (49.5%)Ref
  GA+AA92 (43.8%)106 (50.5%)0.1710.765 (0.511–1.144)0.2040.874 (0.713–1.069)
Allele
  G285257Ref
  A1351630.0430.747 (0.557–1.002)0.0520.862 (0.737–1.001)
  • Notes: “OR*” adjusted by age, sex, alcohol and smoking; CI, confidence interval.