Table 2 Meta-analysis of TNF gene polymorphisms and silicosis
PolymorphismsPopulationsNumber of studiesSample sizeTest of associationTest of heterogeneityEgger’s test (P)
CaseControlOR (95%CI)ZPModelχ2PI2
TNF −308A/GOverall11159114221.348 (1.156–1.570)3.820.000F11.590.31413.7%0.016
A vs. GNANANA1.158 (1.012–1.325)aNANANANANANANA
Asian8110010931.581 (1.288–1.941)4.830.000F5.330.6190.0%0.079
Caucasian23702091.183 (0.897–1.559)1.190.234F0.100.7570.0%NA
African11211200.923 (0.605–1.407)0.370.709NANANANANA
AA vs. AG+GGOverall11159114221.194 (0.752–1.898)0.750.452F5.930.8210.0%0.009
NANANA0.811 (0.536–1.228)aNANANANANANANA
Asian8110010931.689 (0.894–3.226)1.620.106F2.320.9400.0%0.148
Caucasian23702091.024 (0.382–2.744)0.050.962F0.950.3310.0%NA
African11211200.608 (0.228–1.627)0.990.322NANANANANA
AA+AG vs. GGOverall11159114221.466 (1.226–1.753)4.190.000F8.310.5980.0%0.086
Asian8110010931.640 (1.307–2.058)4.270.000F5.190.6370.0%0.118
Caucasian23702091.318 (0.925–1.878)1.530.127F0.000.9860.0%NA
African11211201.021 (0.609–1.712)0.080.936NANANANANA
AA vs. GGOverall11159114221.321 (0.826–2.112)1.160.245F6.150.8020.0%0.010
NANANA1.209 (0.730–2.002)aNANANANANANANA
Asian8110010931.899 (0.995–3.624)1.950.052F2.420.9330.0%0.196
Caucasian23702091.146 (0.417–3.149)0.260.792F0.780.3760.0%NA
African11211200.636 (0.234–1.733)0.880.376NANANANANA
AG vs. GGOverall11159114221.472 (1.222–1.772)4.080.000F6.530.7690.0%0.205
Asian8110010931.611 (1.272–2.040)3.960.000F4.790.6860.0%0.235
Caucasian23702091.325 (0.925–1.900)1.530.125F0.050.8300.0%NA
African11211201.139 (0.655–1.980)0.460.645NANANANANA
TNF −238A/GOverall8119111012.092 (1.232–3.550)2.730.006R21.760.00367.8%0.061
A vs. GAsian67458173.044 (1.234–7.510)2.420.016R20.700.00175.8%0.052
Caucasian13251641.353 (0.994–1.840)1.920.055NANANANANA
African11211201.339 (0.554–3.239)0.650.517NANANANANA
AA vs. AG+GGOverall8119111011.374 (0.562–3.362)0.700.486F1.900.7550.0%0.018
NANANA1.027 (0.440–2.402) a0.57NANANANANANA
Asian67458173.934 (0.614–25.193)1.450.148F0.700.9660.0%0.567
Caucasian13251640.886 (0.256–3.074)0.190.849NANANANANA
African11211200.992 (0.137–7.156)0.010.993NANANANANA
AA+AG vs. GGOverall8119111012.230 (1.297–3.836)2.900.004R19.220.00664.9%0.091
Asian67458173.063 (1.240–7.567)2.430.015R19.880.00174.8%0.051
Caucasian13251641.631 (1.112–2.392)2.500.012NANANANANA
African11211201.454 (0.535–3.956)0.730.463NANANANANA
AA vs. GGOverall8119111011.635 (0.666–4.016)1.070.283F1.800.7720.0%0.044
NANANA1.220 (0.549–2.708)aNANANANANANANA
Asian67458174.591 (0.716–29.452)1.610.108F0.070.9650.0%0.682
Caucasian13251641.145 (0.325–4.027)0.210.833NANANANANA
African11211201.018 (0.141–7.354)0.020.986NANANANANA
AG vs. GGOverall8119111012.205 (1.299–3.743)2.930.003R18.180.01161.5%0.093
Asian67458172.919 (1.222–6.976)2.410.016R18.290.00372.7%0.052
Caucasian13251641.659 (1.125–2.446)2.560.011NANANANANA
African11211201.629 (0.517–5.132)0.830.405NANANANANA
  • F: fixed effects model, R: random effects model, NA: not available.

  • a Adjusted using the “trim and fill” method.