Table 5 Comparison of IL-6 rs1800795 -174 G>C in the study groups
GenotypeMetabolic syndrome, n (%age)Healthy group, n (%age)P valueOR & CI
Co-dominant model
GG92 (41)100 (50)0.027*3 × 2 OR not calculated
GC103(46)88 (44)
CC29 (13)12 (6)
Total224 (100)200 (100)
Allelic frequency
G287 (64)288 (72)0.013*1.44 (1.07–1.93)
C161 (36)112 (28)
Total448(100)400 (100)
Dominant model
GG92 (42)100 (50)0.0581.43 (0.97–2.11)
GC+CC132 (58)100 (50)
Total224 (100)200 (100)
Recessive model
CC29 (12)12 (7)0.016*2.32 (1.15–4.70)
GC+GG195 (88)188 (93)
Total224 (100)200 (100)
  • Chi square test was applied to calculate the ‘P’ value, odds ratio (OR) and confidence interval (CI). A ‘P’ of <0.05 is statistically significant. After continuity correction adjusted P value were calculated by Chi-square test for the IL-6 co-dominant (P=0.024) and recessive model (P=0.025). The association remained significant.