Table 6 Univariate proportional hazard analysis stratified by host characteristics for the association of H19 polymorphisms and HCC
GeneSNPStratifiedStratified factorsGenotypeHCC (n (%))Deaths (n)MSTa(M)P-valueHazard ratio (95% CI)
H19rs2735971
GenderMaleGG160 (69.57)6747.01 (Ref.)
AG64 (27.83)2852.00.6690.91 (0.58–1.41)
AA6 (2.60)233.00.7781.23 (0.30–5.04)
FemaleGG33 (58.93)1338.01 (Ref.)
AG21(37.50)932.00.9181.05 (0.45–2.45)
AA2 (3.57)0NANANA
Age≤60GG109 (63.01)4347.01 (Ref.)
AG58 (33.53)2848.00.5991.14 (0.71–1.83)
AA6 (3.46)125.8b0.8440.82 (0.11–6.03)
>60GG84 (74.34)3745.01 (Ref.)
AG27 (23.89)956.00.2760.67 (0.32–1.38)
AA2 (1.77)133.00.8470.82 (0.11–6.02)
SmokingEver smokerGG17 (62.96)697.1b1 (Ref.)
AG8 (29.63)1117.2b0.2640.30 (0.04–2.49)
AA2 (7.41)0NANANA
Never smokedGG99 (66.44)3581.3b1 (Ref.)
AG46 (30.87)2032.00.7021.11 (0.64–1.93)
AA4 (2.69)133.00.6650.65 (0.09–4.72)
Alcohol drinkingDrinkerGG9 (60.00)2NA1 (Ref.)
AG4 (26.67)0NANANA
AA2 (13.33)0NANANA
Non-drinkerGG107 (66.46)3984.5b1 (Ref.)
AG50 (31.06)2148.00.9190.97 (0.57–1.66)
AA4 (2.48)133.00.6480.63 (0.09–4.59)
HBVPositiveGG86 (65.15)3188.1b1 (Ref.)
AG40 (30.30)1390.00.3310.73 (0.38–1.39)
AA6 (4.55)164.1b0.5520.55 (0.07–4.02)
NegativeGG19 (63.33)727.01 (Ref.)
AG11 (36.67)425.7b0.8031.17 (0.34–4.09)
AA00NANANA
H19rs2839698
GenderMaleCC157 (56.07)6156.01 (Ref.)
CT110 (39.29)5047.00.6921.08 (0.74–1.57)
TT13 (4.64)297.5b0.0870.29 (0.07–1.20)
FemaleCC25 (39.06)855.01 (Ref.)
CT34 (53.13)1151.00.9091.05 (0.42–2.63)
TT5 (7.81)45.00.0703.14 (0.91–10.85)
Age≤60CC111 (51.63)4256.01 (Ref.)
CT94 (43.72)4348.00.6141.12 (0.73–1.71)
TT10 (4.65)291.4b0.2330.42 (0.10–1.75)
>60CC71 (55.04)2756.01 (Ref.)
CT50 (38.76)1879.4b0.8380.94 (0.52–1.71)
TT8 (6.20)427.00.6811.25 (0.44–3.58)
SmokingEver smokerCC16 (50.00)2127.1b1 (Ref.)
CT16 (50.00)945.00.0355.19 (1.12–24.07)
TT00NANANA
Never smokedCC97 (57.06)3169.01 (Ref.)
CT59 (34.71)2347.00.6241.15 (0.67–1.97)
TT14 (8.23)575.1b0.7920.88 (0.34–2.28)
Alcohol drinkingDrinkerCC12 (63.16)170.2b1 (Ref.)
CT7 (36.84)445.00.1105.99 (0.67–53.96)
TT00NANANA
Non-drinkerCC101 (55.19)3269.01 (Ref.)
CT68 (37.16)2848.00.3391.28 (0.77–2.13)
TT14 (7.65)575.1b0.9270.96 (0.37–2.47)
HBVPositiveCC70 (52.24)1994.3b1 (Ref.)
CT55 (41.04)2452.00.1251.60 (0.88–2.93)
TT9 (6.72)378.7b0.9240.94 (0.28–3.20)
NegativeCC17 (56.67)642.2b1 (Ref.)
CT11 (36.67)358.3b0.8820.90 (0.22–3.65)
TT2 (6.66)22.00.2292.74 (0.53–14.18)
H19rs3024270
GenderMaleGG114 (40.14)4556.01 (Ref.)
CG131 (46.13)5748.00.9460.99 (0.67–1.46)
CC39 (13.73)1290.00.2330.68 (0.36–1.28)
FemaleGG17 (26.15)455.01 (Ref.)
CG28 (43.08)1051.00.5321.45 (0.45–4.65)
CC20 (30.77)927.00.0862.83 (0.87–9.28)
Age≤60GG79 (36.41)2886.7b1 (Ref.)
CG99 (45.62)4448.00.9261.02 (0.64–1.65)
CC39 (17.97)1590.00.6111.18 (0.63-2.21)
>60GG52 (39.39)2155.01 (Ref.)
CG60 (45.46)2376.8b0.9460.98 (0.54–1.77)
CC20 (15.15656.6b0.3700.66 (0.27–1.64)
SmokingEver smokerGG7 (21.21)0NA1 (Ref.)
CG21 (63.64)10NANANA
CC5 (15.15)1NANANA
Never smokedGG65 (37.79)2086.3b1 (Ref.)
CG71 (41.28)2747.00.7101.12 (0.63–1.99)
CC36 (20.93)1390.00.9781.01 (0.50–2.04)
Alcohol drinkingDrinkerGG7 (36.84)0NA1 (Ref.)
CG10 (52.63)5NA0.298NA
CC2 (10.53)0NANANA
Non-drinkerGG65 (34.95)2091.3b1 (Ref.)
CG82 (44.09)3269.00.5181.20 (0.69–2.11)
CC39 (20.96)1490.00.9391.03 (0.52–2.04)
HBVPositiveGG45 (32.61)1395.0b1 (Ref.)
CG63 (45.65)2569.00.3981.34 (0.68–2.62)
CC30 (21.74)990.00.9510.97 (0.42–2.28)
NegativeGG12 (40.00)444.7b1 (Ref.)
CG13 (43.33)451.5b0.7861.22 (0.29–5.05)
CC5 (16.67)327.00.3582.03 (0.45–9.20)
  • NA, not available. The bold text means the significant results.

    a, MST, median survival time (months);

    b, Mean survival time was provided when MST could not be calculated.