Conserved domains within the NAD+-dependent DNA ligases from bacteria. Image shows the high-resolution structure of E. coli LigA in complex with nicked adenylated DNA from PDB 2OWO, visualized by UCSF Chimera. The various sub-domains of the enzyme are indicated by different colours in the image; the adenylated-DNA molecule is shown in grey. For further information see article e00391. Image kindly provided by Richard Bowater.