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Accepted Manuscript

Correlations of IL-17 and NF-κB gene polymorphisms with susceptibility and prognosis in Acute Respiratory Distress Syndrome in a Chinese population

Meimei Xie, Bihuan Cheng, Yueping Ding, Changliang Wang, Jianshi Chen
Bioscience Reports Jan 17, 2019, BSR20181987; DOI: 10.1042/BSR20181987
Meimei Xie
The second affiliated hospital and Yuying Children's Hospital of Wenzhou Medical university, Wenzhou, China
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Bihuan Cheng
The second affiliated hospital and Yuying Children's Hospital of Wenzhou Medical university, Wenzhou, California, China
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Yueping Ding
The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, China
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Changliang Wang
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310008, China
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Jianshi Chen
The second affiliated hospital and Yuying Children's Hospital of Wenzhou Medical university, Wenzhou, China
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  • For correspondence: chenjianshi268@sina.com
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Abstract

This study was performed to investigate the association between interleukin-17 (IL-17) and nuclear factor kappa-B (NF-κB) gene polymorphisms and the risk and prognosis of acute respiratory distress syndrome (ARDS) in a Chinese population. A total of 210 Chinese patients with ARDS were selected as the study group, 210 individuals who were identified as at-risk patients but did not meet criteria for ARDS were recruited as the control group. Three single nucleotide polymorphisms (SNPs) of IL-17, including rs763780 (A>G), rs2275913 (G>A), rs8193036 (C>T) and NF-κB1 gene rs3774934 (G>A) loci were examined by Sanger sequencing technique. Patients were followed for 30-day survival. The IL-17 rs763780 and NF-κB1 rs3774934 SNPs had no impact on ARDS risk and prognosis of ARDS ( p >0.05). Compared with individuals carrying the wild-type GG genotype of rs2275913 at IL-17, the AA-homozygous and GA- heterozygous individuals were protected from the development of ARDS. Consistently, a decreased 30-day mortality risk was found among A-allele carriers of rs2275913 at IL-17 ( p <0.05). For IL-17 rs8193036 SNP, the homozygote TT genotype and heterozygote CT genotypes were associated with increased ARDS susceptibility and 30-day mortality risk ( p <0.05). Besides, decreased IL-17 levels were found in A-allele carriers of IL-17 rs2275913, whereas individuals carrying T-allele of IL-17 rs8193036 were found to have significantly increased levels of IL-17 ( p <0.05). Our results suggested that two functional polymorphisms of IL-17, rs2275913 and rs8193036 were associated with ARDS risk and prognosis, indicating that the two genetic variants might act as possible markers for the prediction of ARDS risk and development.

  • IL-17
  • NF-κB1
  • single nucleotide polymorphism
  • acute respiratory distress syndrome
  • ©2019 The Author(s)

This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence.

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Correlations of IL-17 and NF-κB gene polymorphisms with susceptibility and prognosis in Acute Respiratory Distress Syndrome in a Chinese population
Meimei Xie, Bihuan Cheng, Yueping Ding, Changliang Wang, Jianshi Chen
Bioscience Reports Jan 2019, BSR20181987; DOI: 10.1042/BSR20181987
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Correlations of IL-17 and NF-κB gene polymorphisms with susceptibility and prognosis in Acute Respiratory Distress Syndrome in a Chinese population
Meimei Xie, Bihuan Cheng, Yueping Ding, Changliang Wang, Jianshi Chen
Bioscience Reports Jan 2019, BSR20181987; DOI: 10.1042/BSR20181987

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Keywords

IL-17
NF-κB1
Single Nucleotide Polymorphism
acute respiratory distress syndrome

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