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Accepted Manuscript

A Trial Sequential Meta-analysis of TNF- α -308G>A (rs800629) Gene Polymorphism and Susceptibility to Colorectal Cancer

Raju K Mandal, Munawwar Ali Khan, Arif Hussain, Naseem Akhter, Arshad Jawed, Sajad A. Dar, Mohd Wahid, Aditya K. Panda, Mohtashim Lohani, B.N. Mishra, Shafiul Haque
Bioscience Reports Dec 03, 2018, BSR20181052; DOI: 10.1042/BSR20181052
Raju K Mandal
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan, N/A, Saudi Arabia
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Munawwar Ali Khan
College of Natural and Health Sciences, Zayed University, UAE, Dubai, United Arab Emirates
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Arif Hussain
School of Life Sciences, Manipal Academy of Higher Education, UAE, Dubai, United Arab Emirates
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Naseem Akhter
Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha-65431, Saudi Arabia, AlBaha, Saudi Arabia
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Arshad Jawed
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia, JAZAN UNIVERSITY, Jazan, N/A, 45142, Saudi Arabia
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Sajad A. Dar
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia, JAZAN UNIVERSITY, Jazan, N/A, 45142, Saudi Arabia
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Mohd Wahid
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia, JAZAN UNIVERSITY, Jazan, N/A, 45142, Saudi Arabia
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Aditya K. Panda
Centre for Life Sciences, Central University of Jharkhand, Ranchi-835205, Jharkhand, India, Ranchi, N/A, India
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Mohtashim Lohani
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia, JAZAN UNIVERSITY, Jazan, N/A, 45142, Saudi Arabia
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B.N. Mishra
Department of Biotechnology, Institute of Engineering & Technology, Lucknow-226021, Uttar Pradesh, India, Lucknow, N/A, India
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Shafiul Haque
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan, Saudi Arabia
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Abstract

Purpose: Tumor necrosis factor-alpha (TNF-α), secreted by the activated macrophages, may participate in the onset and progression of colorectal cancer (CRC). The association of TNF -α -308 G>A (rs1800629) single nucleotide polymorphism (SNP) with CRC risk has been investigated by many studies but the results are inconclusive. A trial sequential meta-analysis was performed for precise estimation of the relationship between TNF -α -308 G>A gene polymorphism with CRC risk.

Methods: Medline (PubMed), EMBASE (Excerpta-Medica) and Google Scholar were mined for relevant articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the significance of association.

Results: The pooled analysis indicated no risk associated with TNF -α -308 G>A SNP and overall CRC risk in five genetic comparison models, i.e., allelic (A vs. G: p=0.524; OR=1.074, 95% CI=0.863 to 1.335), homozygous (AA vs. GG: p=0.489; OR=1.227, 95% CI=0.688 to 2.188), heterozygous (AG vs. GG: p=0.811; OR=1.024, 95% CI=0.843 to 1.244), dominant (AA+AG vs. GG: p=0.630; OR=1.055, 95% CI=0.849 to 1.311) and recessive (AA vs. AG+GG: p=0.549; OR=1.181, 95% CI=0.686 to 2.033). Subgroup analysis revealed that TNF -α -308 G>A SNP is associated with reduced risk of CRC in Asian ethnicity. The study showed no publication bias.

Conclusions: No association of TNF -α -308 G>A SNP with overall CRC risk was found. This SNP is likely to be protective against CRC in Asian population when compared with Caucasian population. Larger prospective-epidemiological studies are warranted to elucidate the roles of TNF- α -308 G>A SNP in the etiology of CRC and to endorse the present findings.

  • Meta-analysis
  • Tumor Necrosis Factor-ᵯC;
  • Colorectal cancer
  • polymorphism
  • susceptibility
  • ©2018 The Author(s)

This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence.

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A Trial Sequential Meta-analysis of TNF- α -308G>A (rs800629) Gene Polymorphism and Susceptibility to Colorectal Cancer
Raju K Mandal, Munawwar Ali Khan, Arif Hussain, Naseem Akhter, Arshad Jawed, Sajad A. Dar, Mohd Wahid, Aditya K. Panda, Mohtashim Lohani, B.N. Mishra, Shafiul Haque
Bioscience Reports Dec 2018, BSR20181052; DOI: 10.1042/BSR20181052
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A Trial Sequential Meta-analysis of TNF- α -308G>A (rs800629) Gene Polymorphism and Susceptibility to Colorectal Cancer
Raju K Mandal, Munawwar Ali Khan, Arif Hussain, Naseem Akhter, Arshad Jawed, Sajad A. Dar, Mohd Wahid, Aditya K. Panda, Mohtashim Lohani, B.N. Mishra, Shafiul Haque
Bioscience Reports Dec 2018, BSR20181052; DOI: 10.1042/BSR20181052

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Keywords

Meta-analysis
Tumor Necrosis Factor-ᵯC;
Colorectal cancer
polymorphism
Susceptibility

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