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Accepted Manuscript

Genetic susceptibility of five tagSNPs in the endothelin-1 (EDN1) gene to coronary artery disease in a Chinese Han population

Li-li Liang, Lin Chen, Meng-yuan Zhou, Meng-yun Cai, Jie Cheng, Yi Chen, Si-kun You, Lin-bin Chen, Zi-bin Tang, Xi-li Yang, Can Chen, Xinguang Liu, Xing-dong Xiong
Bioscience Reports Apr 13, 2018, BSR20171320; DOI: 10.1042/BSR20171320
Li-li Liang
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Lin Chen
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Meng-yuan Zhou
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Meng-yun Cai
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Jie Cheng
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Yi Chen
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Si-kun You
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Lin-bin Chen
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Zi-bin Tang
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Xi-li Yang
Department of Cardiovascular Disease, The First People's Hospital of Foshan,Foshan 528000, P.R. China, Foshan, China
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Can Chen
Department of Cardiovascular Disease, The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, P.R. China, Zhanjiang, China
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Xinguang Liu
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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Xing-dong Xiong
Department of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Dongguan, China
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  • For correspondence: xiongxingdong@126.com
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Abstract

Endothelin-1 (ET-1) plays important roles in endothelial dysfunction, vascular physiology, inflammation and atherosclerosis. Nonetheless, the role of ET-1 ( EDN1 ) gene variants on coronary artery disease (CAD) risk remains poorly understood. The aim of the present study was to evaluate the role of EDN1 gene polymorphisms on individual susceptibility to CAD. We genotyped five tagSNPs (rs6458155, rs4145451, rs9369217, rs3087459, and rs2070699) within EDN1 gene in 525 CAD patients and 675 control subjects. In a multivariate logistic regression analysis, we detected an association of rs6458155 in EDN1 gene with the CAD risk; compared with the TT homozygotes, the CT heterozygotes [odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.02-2.29, P = 0.040] and the CC homozygotes (OR = 1.55, 95% CI = 1.01-2.36, P = 0.043) were statistically significantly associated with the increased risk for CAD. A similar trend of the association was found in dominant model (OR = 1.53, 95% CI = 1.05-2.25, P = 0.029). Consistently, the haplotype rs6458155C-rs4145451C containing rs6458155 C allele exhibited the increased CAD risk (OR = 1.22, 95% CI = 1.03-1.43, and P = 0.018). In addition, CT genotype of rs6458155 conferred the increased plasma ET-1 levels compared to TT genotype ( P < 0.05). No association of the other four tagSNPs in EDN1 gene with CAD risk was observed. In conclusion, our study provides the first evidence that EDN1 tagSNP rs6458155 is associated with CAD risk in the Chinese Han population, which probably due to influence the circulating ET-1 levels.

  • EDN1
  • single nucleotide polymorphism
  • coronary artery disease
  • risk
  • ©2018 The Author(s)

This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence.

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Genetic susceptibility of five tagSNPs in the endothelin-1 (EDN1) gene to coronary artery disease in a Chinese Han population
Li-li Liang, Lin Chen, Meng-yuan Zhou, Meng-yun Cai, Jie Cheng, Yi Chen, Si-kun You, Lin-bin Chen, Zi-bin Tang, Xi-li Yang, Can Chen, Xinguang Liu, Xing-dong Xiong
Bioscience Reports Apr 2018, BSR20171320; DOI: 10.1042/BSR20171320
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Genetic susceptibility of five tagSNPs in the endothelin-1 (EDN1) gene to coronary artery disease in a Chinese Han population
Li-li Liang, Lin Chen, Meng-yuan Zhou, Meng-yun Cai, Jie Cheng, Yi Chen, Si-kun You, Lin-bin Chen, Zi-bin Tang, Xi-li Yang, Can Chen, Xinguang Liu, Xing-dong Xiong
Bioscience Reports Apr 2018, BSR20171320; DOI: 10.1042/BSR20171320

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Keywords

EDN1
Single Nucleotide Polymorphism
Coronary Artery Disease
risk

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