Gastric cancer is the most common cancer and the most frequent cause of cancer death worldwide. Several studies have identified the role of thymidylate synthase (TS) 5'- and 3'-untranslated region (UTR) and gastric cancer susceptibility, however, the results still remain inconclusive. The purpose of this meta-analysis was to reinvestigate this correlation. In this study, online databases were searched to retrieve relevant articles published between January 2000 and 2016. The odds ratio (OR) and 95% confidence interval (CI) was employed to calculate the strength of association. Overall, a total of thirteen articles were screened out, including 2382 gastric cancer patients and 3171 healthy controls. We found that polymorphisms of TS 5'-UTR 2R/3R (eleven articles) and 3'-UTR del6/ins6 (seven articles) were not significant associated with increased risk of gastric cancer. Subgroup analysis by ethnicity showed that 2R allele and 2R/2R genotype in TS 5'-UTR was associated with gastric cancer susceptibility in Caucasian and Africa populations; del6 allele, del6/del6 and del6/ins6 genotypes were correlated with gastric cancer in Caucasian population. In conclusion, our result suggested that TS polymorphisms might be risk factors for gastric cancer risk in Caucasian population, while this association needs further study, and future large-scale researches are still required.
- gastric cancer
- thymidylate synthase gene
- ©2016 The Author(s)
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