Objective: Whether dietary vitamin A intake could reduce pancreatic cancer risk is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies.
Methods: We searched the databases of PubMed and Web of Knowledge up to July 2016. Random model was used to combine study-specific relative risks (RR) and 95% confidence interval (95% CI). Publication bias was assessed by Egger regression asymmetry test and Begg's funnel plot.
Results: Eleven studies (10 case-control studies and 1 cohort studies) involving 2705 pancreatic cancer cases were included in this study. The RR (95% CI) of pancreatic cancer for highest category of vitamin A intake versus lowest category was 0.839 (95% CI= 0.712-0.988) with low heterogeneity detected (I2= 17.8%, P heterogeneity = 0.274). The relationship were also significant for studies designed by case-control [RR=0.808, 95% CI= 0.690-0.947], as well as in European population [RR=0.821, 95% CI= 0.693-0.972]. No evidence of publication bias was found.
Conclusions: This meta-analysis demonstrated that dietary vitamin A intake might inversely associated with the risk of pancreatic cancer.
- Vitamin A
- pancreatic cancer
- ©2016 The Author(s)
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