Objectives: This study determines the prevalence of vascular dysfunction and arterial stiffness in a female urban population by measuring the brachial augmentation index (AIx) and aortic pulse wave velocity (PWV). The study tests the hypothesis that the measurement of AIx and PWV is useful in addition to that of traditional cardiovascular risk factors when assessing the risk for left ventricular diastolic dysfunction (LVDD). Methods: This cross-sectional study recruited 965 women aged 25-75 years from a German major city. The arterial stiffness (ASt) indices, brachial AIx, aortic PWV, and the central blood pressure were measured by an oscillometric method. A randomly selected subgroup was examined by echocardiography. Questionnaires, medical history, and blood sampling were used for the evaluation of risk factors. Results: Normal vascular function was found in 55% of the women included. The prevalence of women with pathological AIx only (AIx≥-10%, PWV normal) was 21.5%, while 17.9% were affected by increased AIx and PWV (AIx≥-10%, PWV ≥9.7 m/s), and 6% with only pathological PWV values. The prevalence of LVDD was 31.7%. LVDD was significantly associated with pathological PWV ≥ 9.7 m/s [OR:1.27, 95%CI:1.02-1.57], age [OR:4.17, 95%CI:2.87-6.07], and a waist circumference >80 cm [OR: 3.61, 95%CI:1.85-7.04] in multiple regression analysis. Conclusions: The high prevalence of markers for vascular dysfunction and arterial stiffness in a general female population and their importance as a mediator of diastolic dysfunction should encourage implementation of aortic PWV measurement to improve cardiovascular risk assessment in particular to identify subclinical myocardial diastolic dysfunction.
- arterial stiffness
- vascular dysfunction
- diastolic dysfunction
- ©2016 The Author(s)
This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence.