The Ubiquitin ligase Anaphase Promoting Complex or Cyclosome (APC/C) and the tumor suppressor Retinoblastoma protein (pRB) play key roles in cell cycle regulation. APC/C is a critical regulator of mitosis and G1 phase of the cell cycle while pRB keeps a check on proliferation by inhibiting transition to the S-phase. APC/C and pRB interact with each other via the coactivator of APC/C, FZR1, providing an alternative pathway of regulation of G1 to S transition by pRB using a post-translational mechanism. Both pRB and FZR1 have complex roles and are implicated not only in regulation of cell proliferation but also in differentiation, quiescence, apoptosis, maintenance of chromosomal integrity and metabolism. Both are also targeted by transforming viruses. We discuss recent advances in our understanding of the involvement of APC/C and pRB in cell cycle based decisions and how these insights will be useful for development of anti-cancer and anti-viral drugs.
- Anaphase Promoting Complex/Cyclosome
- cell cycle
- ©2016 The Author(s)
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