Micro-inflammation plays an important role in the pathogenesis of SHR (spontaneously hypertensive rat). In the present study, we investigated the therapeutic potential of RSV, a polyphenol with anti-fibrosis activity in hypertensive renal damage model. In SHR renal damage model, RSV treatment blunted the increases of urine albumin excretion, urinary β2-microglobulin, attenuated the decrease of CCR. The glomerular sclerosis index (1.540.33 vs 0.360.07) and tubulointerstitial fibrosis (1.570.31 vs 0.190.04) were significantly higher in SHRs compared with WKYs (Wistar Kyoto rats), which were significantly lower by RSV treatment. The increases of mesangium accumulation and the expression of renal Col I (collagen type I), Fn (fibronectin), PAI-1 and TGF-β1 in SHR were also reduced by RSV treatment. NF-κB expression was increased in the cytoplasm and nuclei of the SHR kidneys, which was significantly decreased by RSV treatment. Furthermore, the protein level of IκB-α significantly decreased in the kidneys of the SHR when compared with the WKYs. RSV treatment partially restored the decreased IκB-α level. In SHR kidney, increased expression of IL-6, ICAM-1 and MCP-1 were observed. These changes were attenuated by RSV treatment. No changes in blood pressure were detected between SHR group and SHR+RSV group. Taken together, the present study demonstrated that RSV treatment may significantly attenuate renal damage in the SHR model of CKD. The renal protective effect is associated with inhibition of IL-6, ICAM-1 and MCP-1 expression via the regulation of the nuclear translocation of NF-κB, which suggesting that micro-inflammation may be a potential therapeutic target of hypertensive renal damage.
- ©2016 The Author(s)
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