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Review Article

Apical protein transport and lumen morphogenesis in polarized epithelial cells

Carly Willenborg, Rytis Prekeris
Bioscience Reports Mar 02, 2011, 31 (4) ; DOI: 10.1042/BSR20100119
Carly Willenborg
Department of Cell and Developmental Biology, School of Medicine, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, U.S.A.
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Rytis Prekeris
Department of Cell and Developmental Biology, School of Medicine, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, U.S.A.
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Abstract

Segregation of the apical and basolateral plasma membrane domains is the key distinguishing feature of epithelial cells. A series of interrelated cues and processes follow this primary polarization event, resulting in the morphogenesis of the mammalian epithelium. This review focuses on the role of the interactions between the extracellular matrix and neighbouring cells during the initiation and establishment of epithelial polarity, and the role that membrane transport and polarity complexes play in this process. An overview of the formation of the apical junctional complexes is given in relation to the generation of distinct membrane domains characterized by the asymmetric distribution of phosphoinositides and proteins. The mechanisms and machinery utilized by the trafficking pathways involved in the generation and maintenance of this apical-basolateral polarization are expounded, highlighting processes of apical-directed transport. Furthermore, the current proposed mechanisms for the organization of entire networks of cells into a structured, polarized three-dimensional structure are described, with an emphasis on the proposed mechanisms for the formation and expansion of the apical lumen.

  • apical protein
  • endocytic transport
  • epithelial cell
  • lumen
  • plasma membrane
  • polarization

Abbreviations: AEE, apical early endosome; AP1, adaptor protein 1; aPKC, atypical protein kinase C; ARE, apical recycling endosome; BEE, basolateral early endosome; CRB, Crumbs; CRE, common recycling endosome; ECM, extracellular matrix; FIP, family interacting protein; KIF, kinesin superfamily of molecular motor proteins; MDCK, Madin–Darby canine kidney; PALS1, protein associated with Lin Seven 1; PAR, Partioning-defective; PI, phosphoinositide; PI3K, phosphatidylinositide 3-kinase; PIP2, phosphatidylinositol 4,5-bisphosphate; PIP3, phosphatidylinositol 3,4,5-triphosphate; PM, plasma membrane; PTEN, phosphatase and tensin homologue deleted on chromosome 10; SCRB, Scribble; SNARE, soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor; TGN, trans-Golgi network; t-SNARE, target SNARE; VAC, vacuolar apical compartment; v-SNARE, vehicle SNARE

  • © The Authors Journal compilation © 2011 Biochemical Society
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August 2011

Volume: 31 Issue: 4

Bioscience Reports: 31 (4)
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Apical protein transport and lumen morphogenesis in polarized epithelial cells
Carly Willenborg, Rytis Prekeris
Bioscience Reports Aug 2011, 31 (4) 245-256; DOI: 10.1042/BSR20100119
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Apical protein transport and lumen morphogenesis in polarized epithelial cells
Carly Willenborg, Rytis Prekeris
Bioscience Reports Aug 2011, 31 (4) 245-256; DOI: 10.1042/BSR20100119

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  • Article
    • Abstract
    • INTRODUCTION
    • POLARITY COMPLEXES
    • ROLE OF LIPIDS IN POLARIZED EPITHELIAL TRANSPORT
    • ENDOCYTIC SORTING AND TRANSPORT IN EPITHELIAL CELLS
    • THE ROLES OF POLARITY COMPLEXES AND ENDOCYTIC TRANSPORT DURING EPITHELIAL LUMEN MORPHOGENESIS
    • CONCLUSIONS AND FUTURE OBJECTIVES
    • FUNDING
    • Acknowledgments
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Keywords

apical protein
endocytic transport
epithelial cell
lumen
plasma membrane
polarization

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