Wanjin Hong – Editor-in-Chief - Bioscience Reports
Wanjin Hong graduated from Xiamen University (Fujian, China) in 1982 and was one of a few hundred Chinese students chosen for further graduate training in the United States via the CUSBEA program. He received his PhD from the State University of New York (SUNY Buffalo), and was a postdoctoral fellow there before he joined the Institute of Molecular and Cell Biology (IMCB) in Singapore as a principal investigator in 1989. At present, he is a Professor and Deputy Director of IMCB, which is governed by the Agency for Science, Technology and Research (A*STAR), a lead agency in Singapore fostering scientific research and talent. He is also a Professor of the Department of Biochemistry of the National University of Singapore.
His works focus on the molecular mechanisms governing protein trafficking in the secretory and endocytic pathways. His work in the early 1990s identified the Golgi-targeting motifs for TGN38 and Golgi sugar transferases. Biochemical, cell biological and systems biological approaches enabled his laboratory in the late 1990s to identify and characterize approximately half of the 38 SNAREs in mammalian cells involved in vesicle docking and fusion. A gene knockout approach in mice has allowed his laboratory to demonstrate that endobrevin (VAMP8) is a major v-SNARE responsible for regulated exocytosis in exocrine tissues. His group has recently identified a number of novel PX (phox) domain-containing sorting nexins (SNXs), and is among the first few laboratories to establish that the PX domain is a novel structural module capable of interacting with phosphoinositides. His group also studies the function and mechanism of small GTPases, such as Arl1, Rab7 and Rab34, and has demonstrated that Arl1 regulates Golgi targeting of the GRIP domain-containing proteins Golgin-97 and Golgin-245, and that Rab7 and Rab34 share a common downstream effector (RILP). His current and future work will focus on the interface of membrane traffic and human diseases, such as cancer.
His scientific contributions were recognized by his receipt of the National Science Award in 1999 in Singapore. He is a member of the editorial board for several other journals, such as the Journal of Biological Chemistry (JBC), Traffic and Molecular Membrane Biology (MMB).
He is currently a member of American Society of Cell Biology (ASCB), American Society for Biochemistry and Molecular Biology (ASBMB), American Association for Cancer Research (AACR), the International Molecular Biology Network (IMBN), the Tan Kah Kee International Society and the Chinese Biological Investigators Society (CBIS).