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Bioscience Reports would like to invite the submission of original papers on all areas of RNA research. Research articles and reviews are welcomed.
Submissions should be made via the Journal's online submission site, ideally by the 1st JULY 2015, and should mention the submission is in response to a call for papers. All submissions will undergo the Journal's normal peer review process.
Identification of signalling cascades involved in red blood cell shrinkage and vesiculation
Elena B. Kostova, Boukje M. Beuger, Thomas R.L. Klei, Pasi Halonen, Cor Lieftink, Roderick Beijersbergen, Timo K. van den Berg and Robin van Bruggen
After screening two libraries of small bioactive molecules and kinase inhibitors, Kostova et al identified several signalling pathways to be involved in red blood cell shrinkage and vesiculation. These include the Jak-STAT pathway, PI3K-Akt pathway, the Raf-MEK-ERK pathway and GPCR signalling.
G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent
Mohammed Jamshad, Jack Charlton, Yu Pin Lin, Sarah J. Routledge, Zharain Bawa, Timothy J. Knowles, Michael Overduin, Niek Dekker, Tim R. Dafforn, Roslyn M. Bill, David R. Poyner† and Mark Wheatley
It is universally acknowledged that exposing cell-surface receptors to detergent is detrimental. In this study, Jamshad et al have used a polymer to extract the receptor and surrounding lipid as a nanoparticle that provides a novel solution compatible with purification and receptor-based drug discovery assays.
siRNA suppression of hTERT using activatable cell-penetrating peptides in hepatoma cells
Hua Li, Jiwen He, Huimin Yi, Guoan Xiang, Kaiyun Chen, Binsheng Fu, Yang Yang and Guihua Chen
Here, Li et al delivered human telomerase reverse transcriptase (hTERT) siRNA into SMMC-7721 hepatoma cells using a matrix metalloproteinase-2 -activatable cell-penetrating peptide. The siRNA subsequently induced down-regulation of the hTERT gene and G1-arrest, implicating the utility of this delivery system in cancer therapy.
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*2012 Journal Citation Reports, Thomson Reuters