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Bioscience Reports (1986) 6, (775–782) (Printed in Great Britain)

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Hypothesis

Phospholipids as a possible instrument for translocation of nascent proteins across biological membranes

Annie RIETVELD^* and Ben KRUIJFF^†

^*Department of Biochemistry, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands, ^†Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands

Abstract

The interaction of phospholipids with precursor proteins, particularly with the mitochondrial precursor protein apocytochromec is reviewed and integrated with other aspects of protein insertion and translocation, leading to a model for (apo)cytochrome c import into mitochondria, in which phospholipids play a dominant role.

Key words: mitochondrial protein import, (apo)cytochromec, phospholipids