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Bioscience Reports (1985) 5, (783–790) (Printed in Great Britain)

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Human placental tissue stimulates bovine capillary endothelial cell growth, migration and protease production

M. PRESTA, P. MIGNATTI, D. E. MULLINS and D. A. MOSCATELLI

Department of Cell Biology and Kaplan Cancer Center, New York University medical Center, 550 First Ave., 10016, New York, N.Y., USA

Abstract

A crude extract of human placenta has been demonstrated to stimulate growth, motility and the production of the proteases plasminogen activator and collagenase in cultured bovine capillary endothelial cells. These data are in keeping with the presence of an angiogenic factor(s) in human placenta.